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Tg(Myl1-SOD1*G93A)#Amu
Transgene Detail
Nomenclature
Symbol: Tg(Myl1-SOD1*G93A)#Amu
Name: transgene insertion, Antonio Musaro
MGI ID: MGI:5499110
Synonyms: MLC/SOD1G93A
Transgene: Tg(Myl1-SOD1*G93A)#Amu  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/NJ
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myl1-SOD1*G93A)#Amu expresses 1 gene
 
Mutation detailsThe human SOD1 cDNA with the G93A mutation is under the control of the regulatory elements of the rat Myl1 (MLC1f/3f) gene. Western and Northern blot analysis confirmed expression in skeletal muscle, predominantly in muscles enriched in fast fibers and reduced in slow muscles such as the soleus. (J:143747)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:143747 Dobrowolny G, et al., Skeletal muscle is a primary target of SOD1G93A-mediated toxicity. Cell Metab. 2008 Nov;8(5):425-36
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory