Il17ra^tm1.2Kurs
Targeted Allele Detail

Summary

• Symbol: Il17ra^tm1.2Kurs
• Name: interleukin 17 receptor A; targeted mutation 1.2, Florian C Kurschus
• MGI ID: MGI:5498882
• Synonyms: IL-17RA^del
• Gene: Il17ra Location: Chr6:120440143-120460692 bp, + strand Genetic Position: Chr6, 56.95 cM
• Alliance: Il17ra^tm1.2Kurs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196483
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomyocin resistance cassette with a 5' loxP site was inserted usptream of exon 4. An additional loxP site was inserted downstream of exon 7. Cre-mediated recombination removed exons 4 through 7 and the neomycin resistance cassette. RT-PCR confirmed the absence of transcript expresion in the spleen. (J:196483)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17ra Mutation: 46 strains or lines available

References

• Original: J:196483 El Malki K, et al., An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling. J Invest Dermatol. 2013 Feb;133(2):441-51
• All: 3 reference(s)