Clp1^{tm2e(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Clp1^{tm2e(EUCOMM)Hmgu}
• Name: CLP1, cleavage and polyadenylation factor I subunit; targeted mutation 2e, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5497197
• Gene: Clp1 Location: Chr2:84553466-84557631 bp, - strand Genetic Position: Chr2, 49.45 cM
• IMPC: Clp1 gene page

Mutation origin

• Mutant Cell Lines: HEPD0876_2_A01, HEPD0876_2_A02, HEPD0876_2_A03, HEPD0876_2_A07, HEPD0876_2_B01, HEPD0876_2_B06, HEPD0876_2_B10, HEPD0876_2_C01, HEPD0876_2_C03, HEPD0876_2_C04, HEPD0876_2_C10, HEPD0876_2_D01, HEPD0876_2_D02, HEPD0876_2_D05, HEPD0876_2_E05, HEPD0876_2_G01, HEPD0876_2_G05, HEPD0876_2_G07, HEPD0876_2_H02, HEPD0876_2_H05, HEPD0876_2_H07
• Germline Transmission: Unknown
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 84555048 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clp1 Mutation: 18 strains or lines available

References

• Original: J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015
• All: 1 reference(s)