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Tg(Chat-EGFP/Rpl10a,Slc18a3)DW167Htz
Transgene Detail
Nomenclature
Symbol: Tg(Chat-EGFP/Rpl10a,Slc18a3)DW167Htz
Name: transgene insertion DW167, Nathaniel Heintz
MGI ID: MGI:5496680
Synonyms: ChAT-DW167, Tg(Chat-EGFP/Rpl10a)DW167Htz
Transgene: Tg(Chat-EGFP/Rpl10a,Slc18a3)DW167Htz  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Reporter)
Mutation:    Insertion
 
Mutation detailsTransgenic mice were generated using modified BAC Rp23-431D9. EGFP fused to the ribosomal protein L10a was inserted in the BAC in such a way that expression was driven by Chat. The BAC used to generate the construct includes the vesicular acetylcholine transporter gene (Slc18a3 or VAChT). Slc18a3 is located in the intron between the first and second exons of the Chat gene and is under the control of the Chat promoter. VAChT protein is overexpressed in the hippocampus and brainstem. (J:150403)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:150403 Doyle JP, et al., Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell. 2008 Nov 14;135(4):749-62
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory