Rhcg^tm1Tigm
Targeted Allele Detail

Summary

• Symbol: Rhcg^tm1Tigm
• Name: Rhesus blood group-associated C glycoprotein; targeted mutation 1, Texas A&M Institute for Genomic Medicine
• MGI ID: MGI:5496356
• Gene: Rhcg Location: Chr7:79243111-79267405 bp, - strand Genetic Position: Chr7, 45.09 cM
• Alliance: Rhcg^tm1Tigm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196009
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: A lacZ and neomycin resistance cassette replaced exon 1. Immunohistochemistry confirmed the absence of protein expression in the kidneys. (J:196009)

Generation of the Rhcg^tm1Tigm allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhcg Mutation: 20 strains or lines available

References

• Original: J:196009 Bourgeois S, et al., Haploinsufficiency of the ammonia transporter Rhcg predisposes to chronic acidosis: Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting duct. J Biol Chem. 2013 Feb 22;288(8):5518-29
• All: 3 reference(s)