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Targeted Allele Detail
Symbol: Rhcgtm1Tigm
Name: Rhesus blood group-associated C glycoprotein; targeted mutation 1, Texas A&M Institute for Genomic Medicine
MGI ID: MGI:5496356
Gene: Rhcg  Location: Chr7:79593363-79617657 bp, - strand  Genetic Position: Chr7, 45.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:196009
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ and neomycin resistance cassette replaced exon 1. Immunohistochemistry confirmed the absence of protein expression in the kidneys. (J:196009)
Generation of the Rhcgtm1Tigm allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rhcg Mutation:  1 strain or line available
Original:  J:196009 Bourgeois S, et al., Haploinsufficiency of the ammonia transporter Rhcg predisposes to chronic acidosis: Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting duct. J Biol Chem. 2013 Feb 22;288(8):5518-29
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory