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Fcmrtm1Mak
Targeted Allele Detail
Summary
Symbol: Fcmrtm1Mak
Name: Fc fragment of IgM receptor; targeted mutation 1, Tak Mak
MGI ID: MGI:5496253
Synonyms: Toso-
Gene: Fcmr  Location: Chr1:130793514-130808528 bp, + strand  Genetic Position: Chr1, 56.89 cM, cytoband E4
Alliance: Fcmrtm1Mak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194323
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced almost the entire coding region, extending from an intron in the 5' leader sequence pasted the last methionine codon. PCR and RT-PCR of various tissue extracts confirmed gene deletion. (J:194323)
Generation of the Fcmrtm1Mak allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fcmr Mutation:  26 strains or lines available
References
Original:  J:194323 Lang KS, et al., Involvement of Toso in activation of monocytes, macrophages, and granulocytes. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2593-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory