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Palb2tm1.1Dli
Targeted Allele Detail
Nomenclature
Symbol: Palb2tm1.1Dli
Name: partner and localizer of BRCA2; targeted mutation 1.1, David M Livingston
MGI ID: MGI:5495825
Synonyms: Palb2fl
Gene: Palb2  Location: Chr7:122107262-122132980 bp, - strand  Genetic Position: Chr7, 65.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:197442
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a loxP site upstream of exon 2, and a second loxP site, followed by a frt-flanked neomycin resistance (neo) cassette, downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette. (J:197442)
Generation of the Palb2tm1.1Dli allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Palb2 Mutation:  30 strains or lines available
References
Original:  J:197442 Bowman-Colin C, et al., Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8632-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory