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Targeted Allele Detail
Symbol: Palb2tm1.1Dli
Name: partner and localizer of BRCA2; targeted mutation 1.1, David M Livingston
MGI ID: MGI:5495825
Synonyms: Palb2fl
Gene: Palb2  Location: Chr7:122107262-122132980 bp, - strand  Genetic Position: Chr7, 65.42 cM
Germline Transmission:  Earliest citation of germline transmission: J:197442
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert a loxP site upstream of exon 2, and a second loxP site, followed by a frt-flanked neomycin resistance (neo) cassette, downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette. (J:197442)
Generation of the Palb2tm1.1Dli allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Palb2 Mutation:  30 strains or lines available
Original:  J:197442 Bowman-Colin C, et al., Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8632-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory