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Targeted Allele Detail
Symbol: Ddctm1.1Nwlh
Name: dopa decarboxylase; targeted mutation 1.1, Wuh-Liang Hwu
MGI ID: MGI:5495816
Synonyms: DdcIVS6
Gene: Ddc  Location: Chr11:11814101-11898044 bp, - strand  Genetic Position: Chr11, 7.09 cM, cytoband A1-A4
Germline Transmission:  Earliest citation of germline transmission: J:197646
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Single point mutation
Mutation detailsIntron 6 was replaced with a modified intron 6 with a mutation (A to T) 4 nucleotides into the intron affecting the exon 6 splice acceptor site, and a floxed neomycin resistance cassette. Cre-mediated recombination removed the neomycin resistance cassette. Western blot analysis confirmed the lack of expression in the substantia nigra. (J:197646)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddc Mutation:  110 strains or lines available
Original:  J:197646 Lee NC, et al., Regulation of the dopaminergic system in a murine model of aromatic L-amino acid decarboxylase deficiency. Neurobiol Dis. 2013 Apr;52:177-90
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory