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Targeted Allele Detail
Symbol: Ddctm1.1Nwlh
Name: dopa decarboxylase; targeted mutation 1.1, Wuh-Liang Hwu
MGI ID: MGI:5495816
Synonyms: DdcIVS6
Gene: Ddc  Location: Chr11:11814101-11898044 bp, - strand  Genetic Position: Chr11, 7.09 cM, cytoband A1-A4
Germline Transmission:  Earliest citation of germline transmission: J:197646
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Single point mutation
Mutation detailsIntron 6 was replaced with a modified intron 6 with a mutation (A to T) 4 nucleotides into the intron affecting the exon 6 splice acceptor site, and a floxed neomycin resistance cassette. Cre-mediated recombination removed the neomycin resistance cassette. Western blot analysis confirmed the lack of expression in the substantia nigra. (J:197646)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddc Mutation:  108 strains or lines available
Original:  J:197646 Lee NC, et al., Regulation of the dopaminergic system in a murine model of aromatic L-amino acid decarboxylase deficiency. Neurobiol Dis. 2013 Apr;52:177-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory