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Raf1tm2Ara
Targeted Allele Detail
Nomenclature
Symbol: Raf1tm2Ara
Name: v-raf-leukemia viral oncogene 1; targeted mutation 2, Toshiyuki Araki
MGI ID: MGI:5495664
Gene: Raf1  Location: Chr6:115618569-115676635 bp, - strand  Genetic Position: Chr6, 53.62 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:189143
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
 
Mutation detailsA targeting vector containing a loxP site, cDNA spanning exons 13 through 16, neo cassette, second loxP site and modified exon 13 was inserted into intron 12. The modified exon 13 contains nucleotide substitution(s) that result in the amino acid substitution of asparagine for aspartic acid at position 486 (D486N). (J:189143)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Raf1 Mutation:  82 strains or lines available
References
Original:  J:189143 Wu X, et al., Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants. Mol Cell Biol. 2012 Oct;32(19):3872-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory