Lrp1^{tm1.1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Lrp1^{tm1.1(KOMP)Wtsi}
• Name: low density lipoprotein receptor-related protein 1; targeted mutation 1.1, Wellcome Trust Sanger Institute
• MGI ID: MGI:5494466
• Gene: Lrp1 Location: Chr10:127374030-127457017 bp, - strand Genetic Position: Chr10, 74.52 cM, cytoband B2-D1
• Alliance: Lrp1^{tm1.1(KOMP)Wtsi} page
• IMPC: Lrp1 gene page

Mutation origin

• Mutant Cell Line: EPD0415_3_C09
• Germline Transmission: Earliest citation of germline transmission: J:188991
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 2563 starting at position 127446152 and ending at position 127448715 of Chromosome 10 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site was followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site, and subsequent Cre-mediated excision removed this neomycin selection cassette. (J:148605, J:173534, J:188991)

Expression

In Mice Carrying this Mutation:	47 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrp1 Mutation: 211 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 5 reference(s)