About   Help   FAQ
Tg(Thy1-APPSweLon)41Ema
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-APPSweLon)41Ema
Name: transgene insertion 41, Eliezer Masliah
MGI ID: MGI:5491622
Synonyms: APP41, mThy1-hAPP751, T41 APP, TASD41
Transgene: Tg(Thy1-APPSweLon)41Ema  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-APPSweLon)41Ema expresses 1 gene
 
Mutation detailsThe murine Thy1 promoter drives expression of the hAPP751 cDNA containing the Swedish (K670N/M671L) and the London (V717I) mutations. Immunohistochemistry confirmed high expression of human APP in the neocortex and hippocampus and moderate expression in the thalamus, basal ganglia, and cerebellum. Three lines were made, 16, 11, and 41. Line 41 is the highest expressing line. (J:162842)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:162842 Rockenstein E, et al., Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42). J Neurosci Res. 2001 Nov 15;66(4):573-82
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/17/2015
MGI 5.21
The Jackson Laboratory