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Map3k8tm1Sley
Targeted Allele Detail
Nomenclature
Symbol: Map3k8tm1Sley
Name: mitogen-activated protein kinase kinase kinase 8; targeted mutation 1, Steven C Ley
MGI ID: MGI:5491226
Synonyms: Map3k8D270A
Gene: Map3k8  Location: Chr18:4331327-4353015 bp, - strand  Genetic Position: Chr18, 2.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:196528
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation detailsNucleotide substitution(s) results in the amino acid substitution of alanine for aspartic acid at position 270 (D270A). (J:196528)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map3k8 Mutation:  24 strains or lines available
References
Original:  J:196528 Yang HT, et al., Coordinate regulation of TPL-2 and NF-kappaB signaling in macrophages by NF-kappaB1 p105. Mol Cell Biol. 2012 Sep;32(17):3438-51
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory