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Transgene Detail
Symbol: Tg(Pten)GPpp
Name: transgene insertion G, Pier Paolo Pandolfi
MGI ID: MGI:5491064
Synonyms: BAC-PTEN TG, BAC-PTEN TG line 3, Super-PTEN, Super-PTEN line 3, Tg(RP23-215F15)GPpp
Transgene: Tg(Pten)GPpp  Location: unknown  
Strain of Origin:  (C57BL/6 x CBA)F2
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Pten)GPpp expresses 1 gene
Mutation detailsThe transgene comprises the 218.50-kb mouse genomic DNA insert of the bacterial artificial chromosome (BAC) clone RP23-215F15 (RPCI library; C57BL/6J), which contains the entire phosphatase and tensin homolog (Pten) gene. Immunoblot analysis of whole-cell protein extracts from mouse embryonic fibroblasts (MEFs) cultured from E13.5 embryos of this line shows that they express the protein at 3.5-fold the level of wild-type MEFs; elevated levels are observed in both cytoplasmic and nuclear MEF extracts. Elevated PTEN protein expression is observed in embryos and in all adult tissues analyzed: brain, lung, kidney, heart, thymus, liver, spleen, and white and brown adipose tissue. (J:186096)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:186096 Garcia-Cao I, et al., Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 2012 Mar 30;149(1):49-62
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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