Tg(Pten)GPpp
Transgene Detail
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| Symbol: |
Tg(Pten)GPpp |
| Name: |
transgene insertion G, Pier Paolo Pandolfi |
| MGI ID: |
MGI:5491064 |
| Synonyms: |
BAC-PTEN TG, BAC-PTEN TG line 3, Super-PTEN, Super-PTEN line 3, Tg(RP23-215F15)GPpp |
| Transgene: |
Tg(Pten)GPpp Location: unknown
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| Alliance: |
Tg(Pten)GPpp page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Pten)GPpp expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Pten (MGI:109583) |
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Mutation details: The transgene comprises the 218.50-kb mouse genomic DNA insert of the bacterial artificial chromosome (BAC) clone RP23-215F15 (RPCI library; C57BL/6J), which contains the entire phosphatase and tensin homolog (Pten) gene. Immunoblot analysis of whole-cell protein extracts from mouse embryonic fibroblasts (MEFs) cultured from E13.5 embryos of this line shows that they express the protein at 3.5-fold the level of wild-type MEFs; elevated levels are observed in both cytoplasmic and nuclear MEF extracts. Elevated PTEN protein expression is observed in embryos and in all adult tissues analyzed: brain, lung, kidney, heart, thymus, liver, spleen, and white and brown adipose tissue.
(J:186096)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:186096 Garcia-Cao I, et al., Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 2012 Mar 30;149(1):49-62 |
| All: |
2 reference(s) |
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Analysis Tools
