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Prg4tm1(GFP/cre/ERT2)Abl
Targeted Allele Detail
Nomenclature
Symbol: Prg4tm1(GFP/cre/ERT2)Abl
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein); targeted mutation 1, Andrew Lassar
MGI ID: MGI:5490969
Synonyms: Prg4GFPCreERt2
Gene: Prg4  Location: Chr1:150325163-150341916 bp, - strand  Genetic Position: Chr1, 63.84 cM, cytoband G
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:197163
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA targeting vector containing a GFP/cre/ERT2 (green fluorescent protein, cre recombinase and estrogen receptor 1 tamoxifen binding domain fusion gene and an FRT flanked PGK-NEO selection cassette), was inserted into the translation initiation codon of exon 2 of the Prg4, proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein). The resulting chimeric animals were crossed to FLP recombinase expressing mice (ACT-FLPe) mice (on an unknown genetic background) to remove the Frt flanked PGK-neo selection cassette. (J:197163)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Prg4     Summary of all recombinase alleles driven by Prg4.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prg4 Mutation:  43 strains or lines available
Notes
ES cells = unspecified 129/SV
References
Original:  J:197163 Lassar A, Generation of cre knockin allele of Prg4. MGI Direct Data Submission. 2013;
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory