Tg(Chrna2-cre)1Kldr
Transgene Detail

Summary

• Symbol: Tg(Chrna2-cre)1Kldr
• Name: transgene insertion 1, Klas Kullander
• MGI ID: MGI:5490768
• Synonyms: Chrna2-cre
• Transgene: Tg(Chrna2-cre)1Kldr Location: unknown
• Alliance: Tg(Chrna2-cre)1Kldr page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Chrna2-cre)1Kldr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Chrna2 (MGI:87886)

• Mutation details: A construct (composed of cre recombinase with a nuclear localization signal, SV40 polyadenylation sequence, and an Frt-Kanamycin/neo-Frt cassette) was introduced into the ATG site in exon 2 of the Chrna2 gene in a bacterial artificial chromosome (BAC RP23-48P22) by recombineering in bacterial cells. Modified BAC DNA was purified and injected into mouse pronuclei to produce transgenic mice. One founder line showed cre expression in cells that express the CHRNA2 protein. (J:193558)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Chrna2 (mouse) Summary of all recombinase alleles driven by Chrna2. Alliance mouse Chrna2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:193558 Leao RN, et al., OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nat Neurosci. 2012 Nov;15(11):1524-30
• All: 10 reference(s)