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Rettm6.1Vpa
Targeted Allele Detail
Nomenclature
Symbol: Rettm6.1Vpa
Name: ret proto-oncogene; targeted mutation 6.1, Vassilis Pachnis
MGI ID: MGI:5489747
Synonyms: Retfl
Gene: Ret  Location: Chr6:118151745-118197718 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195828
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Cre-mediated recombination removed the neo cassette and left exon 1 floxed. (J:195828)
Generation of the Rettm6.1Vpa and Rettm6.2Vpa alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ret Mutation:  35 strains or lines available
References
Original:  J:195828 Almeida AR, et al., RET/GFRalpha signals are dispensable for thymic T cell development in vivo. PLoS One. 2012;7(12):e52949
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory