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Fostm1.1(cre/ERT2)Luo
Targeted Allele Detail
Nomenclature
Symbol: Fostm1.1(cre/ERT2)Luo
Name: FBJ osteosarcoma oncogene; targeted mutation 1.1, Liqun Luo
MGI ID: MGI:5488905
Synonyms: FosCreER, FosCreER, Fos-CreER, FosCreERT2, FosCreERT2, Fos-CreERT2
Gene: Fos  Location: Chr12:85473890-85477273 bp, + strand  Genetic Position: Chr12, 39.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:196644
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to insert a cre/ERT2-SV40 polyA cassette followed by an FRT5-flanked pSV40-NeoR-pA cassette into the translational start site of the FBJ osteosarcoma oncogene gene (Fos). The targeting event displaced the introns and coding regions and replaced the endogenous 3' UTRs (which contribute to mRNA destabilization and to Arc mRNA dendritic trafficking) with an exogenous SV40 polyadenylation signal (to promote high-level expression). All sequences 5' to the translational start site are retained. The construct was electroporated into R1 embryonic stem (ES) cells and correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animals were bred to germline-active GFP-FlpO transgenic mice to delete the FRT5-flanked pSV40-NeoR-pA cassette. (J:196644)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Fos     Summary of all recombinase alleles driven by Fos.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fos Mutation:  23 strains or lines available
References
Original:  J:196644 Guenthner CJ, et al., Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations. Neuron. 2013;78(5):773-784
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory