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Abhd12tm1Crv
Targeted Allele Detail
Nomenclature
Symbol: Abhd12tm1Crv
Name: abhydrolase domain containing 12; targeted mutation 1, Benjamin F Cravatt
MGI ID: MGI:5487621
Gene: Abhd12  Location: Chr2:150832493-150904741 bp, - strand  Genetic Position: Chr2, 74.74 cM
Age-dependent increase in microglial activation in Abhd12tm1Crv/Abhd12tm1Crv brain

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193716
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced exons 8, 9 and 10. Western blot analysis confirmed the absence of protein expression in brain membrane proteosomes. (J:193716)
Generation of the Abhd12tm1Crv allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abhd12 Mutation:  25 strains or lines available
References
Original:  J:193716 Blankman JL, et al., ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1500-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory