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Chemically induced Allele Detail
Symbol: Myo7admbo2
Name: myosin VIIA; dumbo2
MGI ID: MGI:5487403
Synonyms: Myo7aF947I
Gene: Myo7a  Location: Chr7:98051060-98119524 bp, - strand  Genetic Position: Chr7, 53.57 cM
Cochlear morphology in Myo7aewaso/Myo7aewaso and Myo7admbo2/Myo7admbo2 mice

Show the 8 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsENU mutagenesis induced a T to A point mutation that results in the amino acid substitution of isoleucine for phenylalanine at position 487 (F947I). Immunohistochemistry reveals a reduction of protein expression in sensory epithelium. (J:195666)
Inheritance:    Recessive
Schematic diagram showing the location of the Myo7aewaso and Myo7admbo2 mutations
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myo7a Mutation:  28 strains or lines available
Original:  J:195666 Miller KA, et al., Inner ear morphology is perturbed in two novel mouse models of recessive deafness. PLoS One. 2012;7(12):e51284
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory