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Targeted Allele Detail
Symbol: Gjb6tm1.1Mcsa
Name: gap junction protein, beta 6; targeted mutation 1.1, Martine Cohen-Salmon
MGI ID: MGI:5486677
Synonyms: Cx30delta
Gene: Gjb6  Location: Chr14:57123303-57133611 bp, - strand  Genetic Position: Chr14, 30.1 cM
Germline Transmission:  Earliest citation of germline transmission: J:193913
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 3 and a floxed pgk-hygromycin cassette was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed exon 3 and the pgk-hygromycin cassette. Quantitative PCR and western blot analysis indicate the absence of mRNA and protein expression in the inner ear of homozygous mice. Expression of Gjb2 mRNA and protein are reduced in the inner ear of homozygous mice but to a lesser extent than in mice homozygous for Gjb6tm1Kwi. (J:193913)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gjb6 Mutation:  8 strains or lines available
Original:  J:193913 Boulay AC, et al., Hearing is normal without connexin30. J Neurosci. 2013 Jan 9;33(2):430-4
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory