Gjb6^tm1Mcsa
Targeted Allele Detail

Summary

• Symbol: Gjb6^tm1Mcsa
• Name: gap junction protein, beta 6; targeted mutation 1, Martine Cohen-Salmon
• MGI ID: MGI:5486676
• Synonyms: Cx30^fl
• Gene: Gjb6 Location: Chr14:57360760-57370764 bp, - strand Genetic Position: Chr14, 30.1 cM
• Alliance: Gjb6^tm1Mcsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193913
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a floxed pgk-hygromycin cassette was inserted downstream of exon 3 via homologous recombination. Quantitative PCR and immunoblot analysis indicate a decrease in mRNA and protein expression in the inner ear of homozygous mice. Expression of Gjb2 mRNA and protein are also reduced in the inner ear of homozygous mice. (J:193913)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gjb6 Mutation: 20 strains or lines available

References

• Original: J:193913 Boulay AC, et al., Hearing is normal without connexin30. J Neurosci. 2013 Jan 9;33(2):430-4
• All: 4 reference(s)