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Cd28tm1Ltu
Targeted Allele Detail
Nomenclature
Symbol: Cd28tm1Ltu
Name: CD28 antigen; targeted mutation 1, Laurence A Turka
MGI ID: MGI:5485211
Synonyms: Cd28fl
Gene: Cd28  Location: Chr1:60746388-60773359 bp, + strand  Genetic Position: Chr1, 30.52 cM, cytoband C1-C3
Skin inflammation and enlarged lymph nodes and spleen in Cd28tm1Ltu/Cd28tm1Ltu Foxp3tm4(YFP/icre)Ayr/Foxp3+ mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194503
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. (J:194503)
Generation of the Cd28tm1Ltu allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd28 Mutation:  29 strains or lines available
Notes
ES cell line = PB6 (C57BL/6)
References
Original:  J:194503 Zhang R, et al., An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest. 2013 Feb;123(2):580-93
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory