Cdkal1^Gt(6062)Tgen
Gene trapped Allele Detail

Summary

• Symbol: Cdkal1^Gt(6062)Tgen
• Name: CDK5 regulatory subunit associated protein 1-like 1; gene trap 6062, TransGenic
• MGI ID: MGI:5484736
• Gene: Cdkal1 Location: Chr13:29375729-30039657 bp, - strand Genetic Position: Chr13, 12.93 cM, cytoband A3.3
• Alliance: Cdkal1^Gt(6062)Tgen page

Abnormal lipid accumulation in Cdkal1^Gt(6062)Tgen/Cdkal1^Gt(6062)Tgen mice on a high fat diet

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: 6062
• Germline Transmission: Earliest citation of germline transmission: J:195460
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Gene trapped (Null/knockout, Reporter) Mutation: Insertion of gene trap vector Vector: pU-17 Vector Type: gene trap Mutation details: Th pU-17 gene trap vector inserted into intron 3. Western blot analysis confirmed the absence of protein in the liver, brain and islet. (J:195460)

Generation of the Cdkal1^Gt(6062)Tgen allele

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkal1 Mutation: 59 strains or lines available

References

• Original: J:195460 Okamura T, et al., Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetes. PLoS One. 2012;7(11):e49055
• All: 2 reference(s)