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Adam17tm1.2Rain
Targeted Allele Detail
Summary
Symbol: Adam17tm1.2Rain
Name: a disintegrin and metallopeptidase domain 17; targeted mutation 1.2, Elaine W Raines
MGI ID: MGI:5478752
Synonyms: Adam17deltaEx5
Gene: Adam17  Location: Chr12:21373510-21423633 bp, - strand  Genetic Position: Chr12, 8.3 cM
Alliance: Adam17tm1.2Rain page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195050
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into intron 4 and an FRT flanked pgk-neo cassette and loxP site were inserted into intron 5 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exon 5. (J:195050)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 21 assay results
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam17 Mutation:  62 strains or lines available
References
Original:  J:195050 Wilson CL, et al., Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev. 2013 Apr-May;130(4-5):272-89
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory