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Tg(CMV-LITAF*W116G)#Lli
Transgene Detail
Nomenclature
Symbol: Tg(CMV-LITAF*W116G)#Lli
Name: transgene insertion, Lian Li
MGI ID: MGI:5478742
Synonyms: SIMPLE W116G
Transgene: Tg(CMV-LITAF*W116G)#Lli  Location: unknown  Genetic Position: Chr14, Syntenic
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CMV-LITAF*W116G)#Lli expresses 1 gene
 
Mutation detailsThe N-terminal hemagglutinin (HA)-tagged human LITAF with a W116G mutation is under the control of the human cytomegalovirus promoter. Three lines were made and this one is the highest expressing line. Immunoblot analysis of sciatic nerve and Schwann cell lysates confirmed expression and genome walking PCR and sequencing identified that the transgene inserted in a non-coding region on chromosome 14 between Thrb and Nr1d2. The pound symbol (#) is used when line is not specified. (J:194981)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:194981 Lee SM, et al., Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot-Marie-Tooth disease type 1C. Hum Mol Genet. 2013 May 1;22(9):1755-70
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory