G6pc1^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: G6pc1^tm1.1Ics
• Name: glucose-6-phosphatase catalytic subunit 1; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5478554
• Synonyms: G6pc^lox
• Gene: G6pc1 Location: Chr11:101258542-101268729 bp, + strand Genetic Position: Chr11, 64.83 cM
• Alliance: G6pc1^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195257
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 was floxed. Flp-mediated recombination removed the FRT-flanked neo cassette inserted downstream of exon 3. (J:195257)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any G6pc1 Mutation: 18 strains or lines available

References

• Original: J:195257 Mutel E, et al., Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas. J Hepatol. 2011 Mar;54(3):529-37
• All: 18 reference(s)