Usp44^tm1.2Pjgl
Targeted Allele Detail

Summary

• Symbol: Usp44^tm1.2Pjgl
• Name: ubiquitin specific peptidase 44; targeted mutation 1.2, Paul J Galardy
• MGI ID: MGI:5478528
• Gene: Usp44 Location: Chr10:93667417-93693950 bp, + strand Genetic Position: Chr10, 48.67 cM
• Alliance: Usp44^tm1.2Pjgl page

Usp44^tm1.2Pjgl/Usp44^tm1.2Pjgl MEFs exhibit abnormal spindle geometry

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193965
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the neo cassette. (J:193965)

Generation of the Usp44^tm1Pjgl, Usp44^tm1.1Pjgl, and Usp44^tm1.2Pjgl alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Usp44^tm1.2Pjgl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp44 Mutation: 42 strains or lines available

References

• Original: J:193965 Zhang Y, et al., USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. J Clin Invest. 2012 Dec 3;122(12):4362-74
• All: 2 reference(s)