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Targeted Allele Detail
Symbol: Sumo1tm1.1Bros
Name: small ubiquitin-like modifier 1; targeted mutation 1.1, Nils Brose
MGI ID: MGI:5476974
Synonyms: His6-HA-SUMO1
Gene: Sumo1  Location: Chr1:59639434-59670834 bp, - strand  Genetic Position: Chr1, 30.32 cM, cytoband C2-C3
Germline Transmission:  Earliest citation of germline transmission: J:193101
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsSequence encoding for 6 histidines, a trombine cleavage site and a hemagglutinin (HA) tag was inserted in exon 1 in frame 3' of the start codon and a floxed neo cassette was inserted in intron 1 via homologous recombination. Cre mediated recombination removed the neo cassette. A fusion protein is detected in heterozygous mice. Presence of the tag does not appear to effect substrate specificity of SUMO1 conjugation. (J:193101)
Generation of the Sumo1tm1.1Bros allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sumo1 Mutation:  68 strains or lines available
Original:  J:193101 Tirard M, et al., In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21122-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory