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Sumo1tm1.1Bros
Targeted Allele Detail
Nomenclature
Symbol: Sumo1tm1.1Bros
Name: small ubiquitin-like modifier 1; targeted mutation 1.1, Nils Brose
MGI ID: MGI:5476974
Synonyms: His6-HA-SUMO1
Gene: Sumo1  Location: Chr1:59639434-59670834 bp, - strand  Genetic Position: Chr1, 30.32 cM, cytoband C2-C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193101
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsSequence encoding for 6 histidines, a trombine cleavage site and a hemagglutinin (HA) tag was inserted in exon 1 in frame 3' of the start codon and a floxed neo cassette was inserted in intron 1 via homologous recombination. Cre mediated recombination removed the neo cassette. A fusion protein is detected in heterozygous mice. Presence of the tag does not appear to effect substrate specificity of SUMO1 conjugation. (J:193101)
Generation of the Sumo1tm1.1Bros allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sumo1 Mutation:  68 strains or lines available
References
Original:  J:193101 Tirard M, et al., In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21122-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory