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Mutyhtm1Yun
Targeted Allele Detail
Nomenclature
Symbol: Mutyhtm1Yun
Name: mutY DNA glycosylase; targeted mutation 1, Yusaku Nakabeppu
MGI ID: MGI:5476928
Gene: Mutyh  Location: Chr4:116807723-116819440 bp, + strand  Genetic Position: Chr4, 53.34 cM, cytoband C7
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195260
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaces exons 8 through 15. Western blot analysis confirmed the absence of protein expression in ES cells. (J:195260)
Generation of the Mutyhtm1Yun allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mutyh Mutation:  28 strains or lines available
Notes
ES cell = CCE28
References
Original:  J:195260 Hirano S, et al., Mutator phenotype of MUTYH-null mouse embryonic stem cells. J Biol Chem. 2003 Oct 3;278(40):38121-4
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory