Tg(Prnp-PRNP)001Jmto
Transgene Detail

Summary

• Symbol: Tg(Prnp-PRNP)001Jmto
• Name: transgene insertion 001, Juan Maria Torres
• MGI ID: MGI:5476823
• Synonyms: PoPrP-Tg001, Tg(moPrpn PoPrP)001Jmto
• Transgene: Tg(Prnp-PRNP)001Jmto Location: unknown
• Alliance: Tg(Prnp-PRNP)001Jmto page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1 x 129P2/OlaHsd-Prnp^tm2Edin

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-PRNP)001Jmto expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  pig, domestic	PRNP (494014)

• Mutation details: The open reading frame of the porcine prion protein gene was inserted into an expression vector containing the mouse prion protein promoter, exon 1, intron 1, exon 2 and 3' untranslated region. Expression of the porcine prion protein in brains of homozygous transgenic mice, determined by western blot analysis, was fourfold that observed in pig brain homogenate. (J:132565)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:132565 Castilla J, et al., Subclinical bovine spongiform encephalopathy infection in transgenic mice expressing porcine prion protein. J Neurosci. 2004 May 26;24(21):5063-9
• All: 3 reference(s)