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Targeted Allele Detail
Symbol: Nuggctm1.2Diaz
Name: nuclear GTPase, germinal center associated; targeted mutation 1.2, Marilyn Diaz
MGI ID: MGI:5476765
Gene: Nuggc  Location: Chr14:65835995-65885980 bp, + strand  Genetic Position: Chr14, 34.34 cM
Germline Transmission:  Earliest citation of germline transmission: J:190402
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 4. Cre-mediated recombination removed the neo cassette and left exons 2 through 4 floxed. (J:190402)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nuggc Mutation:  26 strains or lines available
Original:  J:190402 Richter K, et al., Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein. J Biol Chem. 2012 Sep 14;287(38):31856-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory