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Trp53tm1Yjc
Targeted Allele Detail
Nomenclature
Symbol: Trp53tm1Yjc
Name: transformation related protein 53; targeted mutation 1, Y Jeffrey Chiang
MGI ID: MGI:5476675
Synonyms: p53rev
Gene: Trp53  Location: Chr11:69580359-69591873 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Trp53tm1Yjc/Trp53tm1Yjc mice develop B cell lymphomas

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195018
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted into exon 1. Western blot analysis confirmed reduced protein expression in the spleen. Cre-mediated recombination is required to restore full expression levels. (J:195018)
Generation of the Trp53tm1Yjc allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  153 strains or lines available
References
Original:  J:195018 Chiang YJ, et al., Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas. PLoS One. 2012;7(11):e49305
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory