Mlana^tm1.1Bee
Targeted Allele Detail

Summary

• Symbol: Mlana^tm1.1Bee
• Name: melan-A; targeted mutation 1.1, Friedrich Beermann
• MGI ID: MGI:5476658
• Synonyms: MART-1^fl, Mlana^loxP
• Gene: Mlana Location: Chr19:29675224-29686034 bp, + strand Genetic Position: Chr19, 24.28 cM, cytoband C2
• Alliance: Mlana^tm1.1Bee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194886
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele, which resulted from FLP recombinase-mediated deletion of a frt site-flanked neomycin resistance cassette, contains loxP sites flanking exon 2, containing the translation initiating ATG, and exon 3; the floxed exons encode the transmembrane domain of the protein. A single frt site remains in intron 1. (J:194886)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mlana Mutation: 9 strains or lines available

References

• Original: J:194886 Aydin IT, et al., Coat color dilution in mice because of inactivation of the melanoma antigen MART-1. Pigment Cell Melanoma Res. 2012 Jan;25(1):37-46
• All: 1 reference(s)