Il7r^tm2Iku
Targeted Allele Detail

Summary

• Symbol: Il7r^tm2Iku
• Name: interleukin 7 receptor; targeted mutation 2, Koichi Ikuta
• MGI ID: MGI:5475476
• Gene: Il7r Location: Chr15:9505874-9530262 bp, - strand Genetic Position: Chr15, 4.16 cM
• Alliance: Il7r^tm2Iku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193283
• Parent Cell Line: KY1.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A cassette containing a loxP site followed by an FRT flanked neomycin resistance gene was inserted 288 bp upstream of exon2 while a second loxP site was inserted 97 bp downstream of exon 2. The neomycin genes was subsequently removed from correctly targeted ES cells using an adenovirus expressing flp recombinase. Exon2 was left flanked by loxP sites. (J:193283)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il7r Mutation: 29 strains or lines available

References

• Original: J:193283 Tani-ichi S, et al., Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):612-7
• All: 3 reference(s)