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Targeted Allele Detail
Symbol: Ei24tm1Hzha
Name: etoposide induced 2.4 mRNA; targeted mutation 1, Hong Zhang
MGI ID: MGI:5475023
Synonyms: Ei24fl, Ei24flox
Gene: Ei24  Location: Chr9:36779159-36797393 bp, - strand  Genetic Position: Chr9, 20.68 cM
Limb-clasping in Ei24tm1Hzha/Ei24tm1Hzha Tg(Nes-cre)1Kln/0 mice

Show the 8 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:193420
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 3. A neo cassette with a 3' loxP site was inserted downstream of exon 3. (J:193420)
Scheme for generating the Ei24tm1Hzha and Ei24tm1.1Hzha alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ei24 Mutation:  41 strains or lines available
Original:  J:193420 Zhao YG, et al., The p53-induced gene Ei24 is an essential component of the basal autophagy pathway. J Biol Chem. 2012 Dec 7;287(50):42053-63
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory