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Pikfyvetm2.1Tssk
Targeted Allele Detail
Nomenclature
Symbol: Pikfyvetm2.1Tssk
Name: phosphoinositide kinase, FYVE type zinc finger containing; targeted mutation 2.1, Takehiko Sasaki
MGI ID: MGI:5474981
Synonyms: PIKfyveFlox, PipkIIIflox
Gene: Pikfyve  Location: Chr1:65186683-65278695 bp, + strand  Genetic Position: Chr1, 32.94 cM, cytoband C3
Hair greying in tamoxifen-treated Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk Tg(Tyr-cre/ERT2)13Bos/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193689
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT flanked selection cassette and loxP site were inserted into intron 37 and a loxP site was inserted into intron 38 via homologous recombination. Flp mediated recombination removed the selection cassette, leaving exon 38 floxed. (J:193689)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pikfyve Mutation:  5 strains or lines available
References
Original:  J:193689 Takasuga S, et al., Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1726-31
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory