Dp(Y)1H
Spontaneous Allele Detail

Summary

• Symbol: Dp(Y)1H
• Name: duplication, Chr Y, 1 Harwell
• MGI ID: MGI:5471229
• Synonyms: 317B.4K
• Gene: Dp(Y)1H Location: unknown Genetic Position: ChrY, Syntenic

Mutation origin

• Strain of Origin: AKR/J and RIII

Mutation description

• Allele Type: Spontaneous
• Mutation: Duplication
• Dp(Y)1H involves 3 genes/genome features (Kdm5d, Zfy2, Sry) View all
• Mutation details: This Y Chromosome (Chr) duplication resulted from asymmetric recombination during male meiosis between the short arm of a Y Chr (Yp) of AKR (M. m. domesticus) origin and an X Chr carrying Tp(Y)1Ct^Sxr-a, which originally occurred in the RIII (M. m. musculus) inbred strain. Southern blot analysis using probes for Yp sequences showed that the recombinant Yp carries both M. m. musculus and M. m. domesticus alleles of Sry, Zfy2 and Kdm5d (formerly Smcy); only the M. m. musculus variant at Zfy1; and only the M. m. domesticus variants of the centromere-proximal Rbmy (formerly Rbm) repeat sequences, demonstrating the presence of a tandem duplication that includes Sry, Zfy2 and Kdm5d. (J:29526)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dp(Y)1H Mutation: 0 strains or lines available

References

• Original: J:29526 Laval SH, et al., Y chromosome short arm-Sxr recombination in XSxr/Y males causes deletion of Rbm and XY female sex reversal. Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10403-7
• All: 1 reference(s)