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Polg2tm1.1Wcc
Targeted Allele Detail
Nomenclature
Symbol: Polg2tm1.1Wcc
Name: polymerase (DNA directed), gamma 2, accessory subunit; targeted mutation 1.1, William C Copeland
MGI ID: MGI:5470227
Gene: Polg2  Location: Chr11:106768253-106779537 bp, - strand  Genetic Position: Chr11, 70.01 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:192568
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 5. A floxed neo cassette was inserted downstream of exon 7. Cre-mediated recombination removed exons 5 through 7. (J:192568)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Polg2 Mutation:  19 strains or lines available
References
Original:  J:192568 Humble MM, et al., Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance. Hum Mol Genet. 2013 Mar 1;22(5):1017-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory