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Targeted Allele Detail
Symbol: Zic3tm2.1Jwb
Name: zinc finger protein of the cerebellum 3; targeted mutation 2.1, John W Belmont
MGI ID: MGI:5470150
Synonyms: Zic3flox
Gene: Zic3  Location: ChrX:58022700-58041736 bp, + strand  Genetic Position: ChrX, 32.56 cM
Germline Transmission:  Earliest citation of germline transmission: J:192577
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:192577)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zic3 Mutation:  37 strains or lines available
Original:  J:192577 Jiang Z, et al., Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development. Hum Mol Genet. 2013 Mar 1;22(5):879-89
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory