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Nol3tm1.1Rnkt
Targeted Allele Detail
Nomenclature
Symbol: Nol3tm1.1Rnkt
Name: nucleolar protein 3 (apoptosis repressor with CARD domain); targeted mutation 1.1, Richard N Kitsis
MGI ID: MGI:5470099
Synonyms: Nol3-
Gene: Nol3  Location: Chr8:105276145-105281939 bp, + strand  Genetic Position: Chr8, 53.04 cM, cytoband D1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193803
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 4. Cre-mediated recombination removed exons 2 through 4 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the lungs. (J:193803)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nol3 Mutation:  7 strains or lines available
References
Original:  J:193803 Zaiman AL, et al., A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension. Circulation. 2011 Dec 6;124(23):2533-42
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory