Ptpn12^tm1.1Vei
Targeted Allele Detail

Summary

• Symbol: Ptpn12^tm1.1Vei
• Name: protein tyrosine phosphatase, non-receptor type 12; targeted mutation 1.1, Andre Veillette
• MGI ID: MGI:5470097
• Gene: Ptpn12 Location: Chr5:21191643-21260909 bp, - strand Genetic Position: Chr5, 9.83 cM, cytoband A3-B
• Alliance: Ptpn12^tm1.1Vei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193767
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an FRT flanked neo-tk selection cassette were inserted in intron 7. A second loxP site was inserted in intron 8. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 8. (J:193767)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn12 Mutation: 50 strains or lines available

References

• Original: J:193767 Souza CM, et al., The phosphatase PTP-PEST/PTPN12 regulates endothelial cell migration and adhesion, but not permeability, and controls vascular development and embryonic viability. J Biol Chem. 2012 Dec 14;287(51):43180-90
• All: 1 reference(s)