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Targeted Allele Detail
Symbol: Syngap1tm2Geno
Name: synaptic Ras GTPase activating protein 1 homolog (rat); targeted mutation 2, Genoway
MGI ID: MGI:5469866
Synonyms: SYNGAP1lx-st
Gene: Syngap1  Location: Chr17:26941253-26972434 bp, + strand  Genetic Position: Chr17, 13.6 cM
Germline Transmission:  Earliest citation of germline transmission: J:193208
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsA floxed neo cassette was inserted into intron 5. Western blot analysis confirmed reduced protein expression in heterozygous samples. Cre-mediated recombination is required to remove the neo cassette and restore protein expression. (J:193208)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Syngap1 Mutation:  27 strains or lines available
Original:  J:193208 Clement JP, et al., Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses. Cell. 2012 Nov 9;151(4):709-23
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory