Gja1^tm9.1Kwi
Targeted Allele Detail

Summary

• Symbol: Gja1^tm9.1Kwi
• Name: gap junction protein, alpha 1; targeted mutation 9.1, Klaus Willecke
• MGI ID: MGI:5469488
• Synonyms: Cx43^fl(ECFP)
• Gene: Gja1 Location: Chr10:56253297-56266519 bp, + strand Genetic Position: Chr10, 28.64 cM
• Alliance: Gja1^tm9.1Kwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193352
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the coding sequence. An FRT-flanked neo cassette, loxP site and ECFP were inserted downstream of the open reading frame. Flp-mediated recombination removed the neo cassette and left the open reading frame floxed and followed by ECFP. (J:193352)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gja1 Mutation: 59 strains or lines available

References

• Original: J:193352 Degen J, et al., Dual reporter approaches for identification of Cre efficacy and astrocyte heterogeneity. FASEB J. 2012 Nov;26(11):4576-83
• All: 1 reference(s)