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Targeted Allele Detail
Symbol: Otoatm1Gpr
Name: otoancorin; targeted mutation 1, Guy P Richardson
MGI ID: MGI:5469411
Synonyms: OtoaEGFP
Gene: Otoa  Location: Chr7:121081650-121163097 bp, + strand  Genetic Position: Chr7, 65.07 cM
The tectorial membrane of Otoatm1Gpr/Otoatm1Gpr mice is detached from spiral limbus

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:192263
Parent Cell Line:  CCB (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn EGFP and neo cassette was inserted downstream of exon 2. Immunohistochemistry confirmed the absence of protein expression in the cochlea. (J:192263)
Generation of the Otoatm1Gpr allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Otoa Mutation:  34 strains or lines available
Original:  J:192263 Lukashkin AN, et al., A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19351-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory