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Targeted Allele Detail
Symbol: Otoatm1Gpr
Name: otoancorin; targeted mutation 1, Guy P Richardson
MGI ID: MGI:5469411
Synonyms: OtoaEGFP
Gene: Otoa  Location: Chr7:121081650-121163097 bp, + strand  Genetic Position: Chr7, 65.07 cM
The tectorial membrane of Otoatm1Gpr/Otoatm1Gpr mice is detached from spiral limbus

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:192263
Parent Cell Line:  CCB (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn EGFP and neo cassette was inserted downstream of exon 2. Immunohistochemistry confirmed the absence of protein expression in the cochlea. (J:192263)
Generation of the Otoatm1Gpr allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Otoa Mutation:  34 strains or lines available
Original:  J:192263 Lukashkin AN, et al., A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19351-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory