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Il7rtm1.1Asin
Targeted Allele Detail
Nomenclature
Symbol: Il7rtm1.1Asin
Name: interleukin 7 receptor; targeted mutation 1.1, Alfred Singer
MGI ID: MGI:5468999
Synonyms: IL-7Rfl
Gene: Il7r  Location: Chr15:9505874-9530262 bp, - strand  Genetic Position: Chr15, 4.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:190889
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3. An FRT- and loxP-flanked neo cassette was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exon 3 floxed. (J:190889)
Generation of the Il7rtm1.1Asin allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il7r Mutation:  19 strains or lines available
References
Original:  J:190889 McCaughtry TM, et al., Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus. J Exp Med. 2012 Nov 19;209(12):2263-76
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory