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Targeted Allele Detail
Symbol: Il7rtm1.1Asin
Name: interleukin 7 receptor; targeted mutation 1.1, Alfred Singer
MGI ID: MGI:5468999
Synonyms: IL-7Rfl
Gene: Il7r  Location: Chr15:9505874-9530262 bp, - strand  Genetic Position: Chr15, 4.16 cM
Germline Transmission:  Earliest citation of germline transmission: J:190889
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 3. An FRT- and loxP-flanked neo cassette was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exon 3 floxed. (J:190889)
Generation of the Il7rtm1.1Asin allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il7r Mutation:  19 strains or lines available
Original:  J:190889 McCaughtry TM, et al., Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus. J Exp Med. 2012 Nov 19;209(12):2263-76
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory