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Casp4tm1.1Vmd
Targeted Allele Detail
Nomenclature
Symbol: Casp4tm1.1Vmd
Name: caspase 4, apoptosis-related cysteine peptidase; targeted mutation 1.1, Vishva M Dixit
MGI ID: MGI:5468949
Synonyms: Casp4tm1.1Gne
Gene: Casp4  Location: Chr9:5308828-5336783 bp, + strand  Genetic Position: Chr9, 2.46 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193522
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upsteam of exon 5. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 5 and the neo cassette. (J:193522)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp4 Mutation:  25 strains or lines available
References
Original:  J:193522 Kayagaki N, et al., Non-canonical inflammasome activation targets caspase-11. Nature. 2011 Nov 3;479(7371):117-21
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory