Cxcl12^tm1.1Link
Targeted Allele Detail

Summary

• Symbol: Cxcl12^tm1.1Link
• Name: C-X-C motif chemokine ligand 12; targeted mutation 1.1, Daniel C Link
• MGI ID: MGI:5468835
• Synonyms: Cxcl12^fl
• Gene: Cxcl12 Location: Chr6:117145496-117158328 bp, + strand Genetic Position: Chr6, 54.81 cM, cytoband F1
• Alliance: Cxcl12^tm1.1Link page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193594
• Parent Cell Line: B6/BLU (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette and left exon 2 floxed. (J:193594)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cxcl12 Mutation: 24 strains or lines available

References

• Original: J:193594 Greenbaum A, et al., CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature. 2013 Mar 14;495(7440):227-30
• All: 25 reference(s)