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Cxcl12tm1.1Link
Targeted Allele Detail
Nomenclature
Symbol: Cxcl12tm1.1Link
Name: chemokine (C-X-C motif) ligand 12; targeted mutation 1.1, Daniel C Link
MGI ID: MGI:5468835
Synonyms: Cxcl12fl
Gene: Cxcl12  Location: Chr6:117145496-117158328 bp, + strand  Genetic Position: Chr6, 54.81 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193594
Parent Cell Line:  B6/BLU (ES Cell)
Strain of Origin:  C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette and left exon 2 floxed. (J:193594)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcl12 Mutation:  21 strains or lines available
References
Original:  J:193594 Greenbaum A, et al., CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature. 2013 Mar 14;495(7440):227-30
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory