Sox17^tm1Mgn
Targeted Allele Detail

Summary

• Symbol: Sox17^tm1Mgn
• Name: SRY (sex determining region Y)-box 17; targeted mutation 1, Mark A Magnuson
• MGI ID: MGI:5468099
• Synonyms: Sox17^LCA
• Gene: Sox17 Location: Chr1:4561154-4567577 bp, - strand Genetic Position: Chr1, 1.65 cM

Mutation origin

• Germline Transmission: Unknown
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (RMCE-ready)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.793 kb region containing exons 3 through 5 was replaced with a puromycin resistance-thymidine kinase fusion gene driven by the mouse phosphoglycerol kinase (PGK) promoter and a kanamycin resistance gene driven by the bacterial EM7 promoter. The selection cassettes were flanked by tandemly oriented lox71 and lox2272 sites. (J:193165)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox17 Mutation: 28 strains or lines available

References

• Original: J:193165 Choi E, et al., Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells. 2012 Oct;30(10):2297-308
• All: 2 reference(s)