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Targeted Allele Detail
Symbol: Ptf1atm3.1(rtTA)Mgn
Name: pancreas specific transcription factor, 1a; targeted mutation 3.1, Mark A Magnuson
MGI ID: MGI:5467924
Gene: Ptf1a  Location: Chr2:19445663-19447501 bp, + strand  Genetic Position: Chr2, 13.37 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:94077
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (RMCE-ready, Transactivator)
Mutation:    Insertion
Mutation detailsA loxP-flanked targeting vector containing a reverse tetracycline transactivator (rtTA) in the 5' UTR and a frt-flanked hygromycin cassette downstream of exon 2 was inserted into Ptf1atm1Mgn (Ptf1aLCA) by recombinant mediated cassette exchange (RMCE). rtTA is expressed under control of the endogenous Ptf1a promoter. The hygromycin cassette was removed by a flp mediated recombination. (J:94077)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptf1a Mutation:  14 strains or lines available
Original:  J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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