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Ptf1atm3.1(rtTA)Mgn
Targeted Allele Detail
Nomenclature
Symbol: Ptf1atm3.1(rtTA)Mgn
Name: pancreas specific transcription factor, 1a; targeted mutation 3.1, Mark A Magnuson
MGI ID: MGI:5467924
Gene: Ptf1a  Location: Chr2:19450474-19452312 bp, + strand  Genetic Position: Chr2, 13.37 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94077
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (RMCE-ready, Transactivator)
Mutation:    Insertion
 
Mutation detailsA loxP-flanked targeting vector containing a reverse tetracycline transactivator (rtTA) in the 5' UTR and a frt-flanked hygromycin cassette downstream of exon 2 was inserted into the loxed cassette acceptor (LCA) allele by recombinant mediated cassette exchange (RMCE). rtTA is expressed under control of the endogenous Ptf1a promoter. The hygromycin cassette was removed by a flp mediated recombination. (J:94077)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptf1a Mutation:  21 strains or lines available
References
Original:  J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory