Lrrk2^tm2.1Mjff
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm2.1Mjff
• Name: leucine-rich repeat kinase 2; targeted mutation 2.1, The Michael J Fox Foundation
• MGI ID: MGI:5466852
• Synonyms: Lrrk2^T1348N
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm2.1Mjff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting vector was designed to introduce a threonine to asparagine (T1348N) substitution at codon 1348 in exon 29 of the endogeneous locus. In addition, an FRT-flanked neomycin resistance (neo) cassette was introduced approximately 200 bp downstream of exon 29. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 163 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 2 reference(s)